International Journal of Molecular Sciences | |
Characterization of Paraquat-Induced miRNA Profiling Response in hNPCs Undergoing Proliferation | |
Min Huang2  Dan Lou2  Qian Cai1  Xiuli Chang2  Xinjin Wang2  Zhijun Zhou2  | |
[1] Department of Occupational and Environmental Health, School of Public Health, Ningxia Medical University, Yinchuan 750000, China; E-Mail:;School of Public Health/MOE Key Lab of Public Health Safety/WHO Collaborating Center for Occupational Health, Fudan University, Shanghai 200032, China; E-Mails: | |
关键词: paraquat; hNPCs; miRNA profiling; developmental neurotoxicity; target genes; biological processes; pathways; | |
DOI : 10.3390/ijms151018422 | |
来源: mdpi | |
【 摘 要 】
Aberration during the development of the central nervous system (CNS) due to environmental factors underlies a variety of adverse developmental outcomes. Paraquat (PQ) is a widely studied neurotoxicant that perturbs the normal structure/function of adult CNS. Yet, the impacts of PQ exposure on the developing CNS remain unclear. miRNAs represent a class of small non-coding RNA molecules involved in the regulation of neural development. Thus in the present study, we analyzed the impacts of PQ on the miRNome of human neural progenitor cells (hNPCs) during proliferation by using the Exiqon miRCURY™ LNA Array. A total of 66 miRNAs were identified as differentially expressed in proliferating hNPCs upon PQ treatment. miRTarBase prediction identified 1465 mRNAs, including several genes (e.g.,
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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