Molecules | |
Biopharmaceutical Profiling of New Antitumor Pyrazole Derivatives | |
Valentina Anuta2  George Mihai Nitulescu1  Cristina Elena Dinu-Pîrvu2  Octavian Tudorel Olaru2  | |
[1] Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, Traian Vuia 6, Bucharest 020956, Romania; | |
关键词: acylthiourea; pyrazole derivatives; solubility; FaSSIF; FeSSIF; ADME prediction; | |
DOI : 10.3390/molecules191016381 | |
来源: mdpi | |
【 摘 要 】
Several new pyrazole derivatives have demonstrated promising antiproliferative and cytotoxic effects, but their poor solubility raised concerns over possible biopharmaceutical limitations. In order to improve their pharmaceutical potential we performed the biopharmaceutical profiling for nine pyrazole compounds using
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190021001ZK.pdf | 1853KB | download |