MicroRNAs Regulate Vascular Medial Calcification

Cells

Jane A. Leopold¹ 

[1] Division of Cardiovascular Medicine, Brigham and Women’s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB0630K, Boston, MA 02115, USA; E-Mail

关键词: microRNAs;    matrix vesicles;    osteoclasts;    vascular smooth muscle cells;    vascular calcification;   

DOI  :  10.3390/cells3040963

来源: mdpi

【 摘 要 】

Vascular calcification is highly prevalent in patients with coronary artery disease and, when present, is associated with major adverse cardiovascular events, including an increased risk of cardiovascular mortality. The pathogenesis of vascular calcification is complex and is now recognized to recapitulate skeletal bone formation. Vascular smooth muscle cells (SMC) play an integral role in this process by undergoing transdifferentiation to osteoblast-like cells, elaborating calcifying matrix vesicles and secreting factors that diminish the activity of osteoclast-like cells with mineral resorbing capacity. Recent advances have identified microRNAs (miRs) as key regulators of this process by directing the complex genetic reprogramming of SMCs and the functional responses of other relevant cell types relevant for vascular calcification. This review will detail SMC and bone biology as it relates to vascular calcification and relate what is known to date regarding the regulatory role of miRs in SMC-mediated vascular calcification.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.