Inhibitory Effect of b-AP15 on the 20S Proteasome

Biomolecules

Li Huang¹  Katherine Jung¹ 

[1] Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA;

关键词: proteasome inhibitor;    b-AP15;    19S regulatory particles;   

DOI  :  10.3390/biom4040931

来源: mdpi

【 摘 要 】

The 26S proteasome is a cellular proteolytic complex containing 19S regulatory particles and the 20S core proteasome. It was reported that the small molecule b-AP15 targets the proteasome by inhibiting deubiquitination of the 19S regulatory particles of the proteasome complex. An investigation of b-AP15 on the 20S proteasome core suggested that this compound can also inhibit the 20S proteasome with a potency equivalent to that found to inhibit the 19S regulatory particles.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.