Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination

Cells

Feng Xie¹  Zhengkui Zhang¹  Hans van Dam²  Long Zhang¹  Fangfang Zhou² 

[1] Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China;Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Postbus 9600 2300 RC Leiden, The Netherlands

关键词: TGF-β;    BMP;    SMAD;    Mono-ubiquitination;   

DOI  :  10.3390/cells3040981

来源: mdpi

【 摘 要 】

TGF-β(transforming growth factor-β) superfamily signaling mediators are important regulators of diverse physiological and pathological events. TGF-β signals are transduced by transmembrane type I and type II serine/threonine kinase receptors and their downstream effectors, the SMAD (drosophila mothers against decapentaplegic protein) proteins. Numerous studies have already demonstrated crucial regulatory roles for modification of TGF-β pathway components by poly-ubiquitination. Recently, several studies also uncovered mono-ubiquitination of SMADs as a mechanism for SMAD activation or inactivation. Mono-ubiquitination and subsequent deubiquitination of SMAD proteins accordingly play important roles in the control of TGF-β superfamily signaling. This review highlights the major pathways regulated by SMAD mono-ubiquitination.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.