Butrepyrazinone, a New Pyrazinone with an Unusual Methylation Pattern from a Ghanaian Verrucosispora sp. K51G

Marine Drugs

Kwaku Kyeremeh¹  Kojo Sekyi Acquah¹  Mustafa Camas³  Jioji Tabudravu²  Wael Houssen²  Hai Deng²  Marcel Jaspars² 

[1] Marine and Plant Laboratory of Ghana, Department of Chemistry, University of Ghana, Accra, P.O. Box LG 56, Ghana; E-Mail:;Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen, AB24 3UE, Scotland, UK; E-Mails:;Department of Bioengineering, Faculty of Engineering, Tunceli University, 62000 Tunceli, Turkey; E-Mail:

关键词: micromonosporaceae;    actinomycete;    pyrazinone;    mangrove;   

DOI  :  10.3390/md12105197

来源: mdpi

【 摘 要 】

We report the structural characterization of a new pyrazinone analogue; butrepyrazinone, which was isolated from a new actinomycete strain Verrucosispora sp. K51G recovered from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of a compound from the fermentation culture and a combination of NMR spectroscopy, high-resolution mass spectrometry and computer-aided calculations revealed that butrepyrazinone (10) possesses an unusual methylation pattern on the pyrazinone ring. Butrepyrazinone (10), however, displayed no antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains, suggesting that 10 may act as a signal molecule for this strain. Although the same molecule has been synthesized previously, this is the first report to disclose the discovery of butrepyrazinone (10) from nature.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.