Current Perspectives on HIV-1 Antiretroviral Drug Resistance

Viruses

Pinar Iyidogan²  Karen S. Anderson¹ 

[1] Department of Pharmacology, School of Medicine, Yale University, New Haven, CT 06520, USA; E-Mail

关键词: HIV-1;    antiviral therapy;    drug resistance;    evolution;    lethal mutagenesis;    resistance monitoring;   

DOI  :  10.3390/v6104095

来源: mdpi

【 摘 要 】

Current advancements in antiretroviral therapy (ART) have turned HIV-1 infection into a chronic and manageable disease. However, treatment is only effective until HIV-1 develops resistance against the administered drugs. The most recent antiretroviral drugs have become superior at delaying the evolution of acquired drug resistance. In this review, the viral fitness and its correlation to HIV-1 mutation rates and drug resistance are discussed while emphasizing the concept of lethal mutagenesis as an alternative therapy. The development of resistance to the different classes of approved drugs and the importance of monitoring antiretroviral drug resistance are also summarized briefly.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.