International Journal of Molecular Sciences | |
Hyperhomocysteinemia Accelerates Collagen Accumulation in the Adventitia of Balloon-Injured Rat Carotid Arteries via Angiotensin II Type 1 Receptor | |
Dan Yao2  Ning-Ling Sun1  | |
[1] Department of Cardiology, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District of Beijing, Beijing 100044, China; E-Mail | |
关键词: hyperhomocysteinemia; homocysteine; adverntitia; collagen; Ang II type 1 receptor; | |
DOI : 10.3390/ijms151119487 | |
来源: mdpi | |
【 摘 要 】
Recent studies suggest that hyperhomocysteinemia (HHcy) increases collagen type I accumulation in rat vascular adventitia after balloon injury and that Angiotensin II (Ang II) induces collagen synthesis in vascular adventitial fibroblasts. Reports also indicate that Ang II type1 receptor (AT1R) activation, mediated by homocysteine (Hcy) may contribute to collagen type 1 expression in mouse aortic endothelial cells. However, little is known about the possible mechanisms behind the relationship between Hcy and AT1R in adventitial remodeling. Thus, we investigated whether HHcy induces collagen accumulation via activation of AT1R in the adventitia. Male Sprague-Dawley (SD) rats were randomly divided into a control group and a 1%
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
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