A Comparison of the Effects of Oral Glutamine Dipeptide, Glutamine, and Alanine on Blood Amino Acid Availability in Rats Submitted to Insulin-Induced Hypoglycemia

Nutrients

Vania C. Minguetti-Câmara²  Any de C. R. Marques²  Fabiana P. M. Schiavon²  Vanessa R. Vilela²  Marcos L. Brusch¹ 

[1] Department of Pharmacy, State University of Maringá, Maringá, Paraná State 87020-900, Brazil; E-Mail:;Department of Pharmacology and Therapeutic, State University of Maringá, Maringá, Paraná State 87020-900, Brazil; E-Mails:

关键词: glutaminedipeptide;    aminoacidemia;    glutamine;    alanine;    hypoglycemia;    liver;   

DOI  :  10.3390/nu6104520

来源: mdpi

【 摘 要 】

We compared the effects of oral administration of high-dose or low-dose glutamine dipeptide (GDP), alanine (ALA), glutamine (GLN), and ALA + GLN on the blood availability of amino acids in rats submitted to insulin-induced hypoglycemia (IIH). Insulin detemir (1 U/kg) was intraperitoneally injected to produce IIH; this was followed by oral administration of GDP, GLN + ALA, GLN, or ALA. We observed higher blood levels of GLN, 30 min after oral administration of high-dose GDP (1000 mg/kg) than after administration of ALA (381 mg/kg) + GLN (619 mg/kg), GLN (619 mg/kg), or ALA (381 mg/kg). However, we did not observe the same differences after oral administration of low-dose GDP (100 mg/kg) compared with ALA (38.1 mg/kg) + GLN (61.9 mg/kg), GLN (61.9 mg/kg), or ALA (38.1 mg/kg). We also observed less liver catabolism of GDP compared to ALA and GLN. In conclusion, high-dose GDP promoted higher blood levels of GLN than oral ALA + GLN, GLN, or ALA. Moreover, the lower levels of liver catabolism of GDP, compared to ALA or GLN, contributed to the superior performance of high-dose GDP in terms of blood availability of GLN.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.