Molecules | |
Ionization States, Cellular Toxicity and Molecular Modeling Studies of Midazolam Complexed with Trimethyl-β-Cyclodextrin | |
Sergey Shityakov1  Tamás Sohajda2  István Puskás2  Norbert Roewer1  Carola Förster1  Jens-Albert Broscheit1  | |
[1] Department of Anaesthesia and Critical Care, University of Würzburg, 97080 Würzburg, Germany; E-Mails:;CycloLab Cyclodextrin Research & Development Laboratory Ltd., H-1097 Budapest, Hungary; E-Mails: | |
关键词: trimethyl-β-cyclodextrin; midazolam; transition state; molecular docking; Gibbs free energy of binding; quantum mechanics; free energy of solvation; torsional energy; | |
DOI : 10.3390/molecules191016861 | |
来源: mdpi | |
【 摘 要 】
We investigated the ionization profiles for open-ring (OR) and closed-ring (CR) forms of midazolam and drug-binding modes with heptakis-(2,3,6-tri-
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190020548ZK.pdf | 782KB | download |