CA15.3 Serum Concentrations in Older Women with Infiltrating Ductal Carcinomas of the Breast

International Journal of Molecular Sciences

Álvaro Ruibal¹  Pablo Aguiar¹  Mar໚ Carmen Del Río⁴  Mar໚ Elena Padín-Iruegas²  José Ignacio Arias³  Michel Herranz¹ 

[1] Molecular Imaging Group, F. Medicine, University of Santiago Compostela, R/de San Francisco, s/n, Santiago de Compostela 15782, Spain; E-Mails:;Anatomía Humana Area, University of Vigo, Lagoas-Marcosende, s/n, Vigo 36310, Spain; E-Mail:;Surgery Department, Hospital of Monte Naranco, Av Fernández Vega, 107, Oviedo 33012, Spain; E-Mail:;General Lab, H. Virgen Xunqueira, P/Pepe Sánchez, 7, Cee, A Coruña 15270, Spain; E-Mail:

关键词: breast cancer;    ductal carcinoma;    CA15.3;    elderly;   

DOI  :  10.3390/ijms151119870

来源: mdpi

【 摘 要 】

Breast cancer is currently becoming a disease of the elderly. We have studied the relation between CA 15.3 serum concentrations and clinical-pathological parameters in 69 women with IDC aged over 70 years (76.3 ± 4.2; range: 71–88; median 76). A group of 205 women with the same tumor but aged <70 years (62.8 ± 4.0; range: 55–70; median 63) was also considered for comparison. Tumor size, axillary lymph node involvement, distant metastasis and histological grade were taken account. Serum CA 15.3 was determined by luminescence assay. CA 15.3 serum concentrations ranged between 6 and 85 U/mL (median 22.9 U/mL), and were higher only in patients with greater (qualitative and quantitative; p: 0.041) tumor size. Our results show that in women with IDCs, and aged over 70 years, serum CA 15.3 serum concentrations are associated exclusively with a greater tumor size, being these findings different to those described in women with the same subtype of tumor considered as a whole or with lower age.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.