Biomedicines | |
HGF–Met Pathway in Regeneration and Drug Discovery | |
Kunio Matsumoto2  Hiroshi Funakoshi1  Hisaaki Takahashi1  Katsuya Sakai2  | |
[1] Center for Advanced Research and Education, Asahikawa Medical University, Asahikawa 078-8510, Japan; E-Mails:;Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa 920-1192, Japan; E-Mail: | |
关键词: amyotrophic lateral sclerosis; clinical trial; HGF; Met; spinal cord injury; | |
DOI : 10.3390/biomedicines2040275 | |
来源: mdpi | |
【 摘 要 】
Hepatocyte growth factor (HGF) is composed of an α-chain and a β-chain, and these chains contain four kringle domains and a serine protease-like structure, respectively. Activation of the HGF–Met pathway evokes dynamic biological responses that support morphogenesis (e.g., epithelial tubulogenesis), regeneration, and the survival of cells and tissues. Characterizations of conditional
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190020231ZK.pdf | 1429KB | download |