A New Prenylated Indole Diketopiperazine Alkaloid from Eurotium cristatum

Molecules

Xianwei Zou²  Ying Li²  Xiaona Zhang²  Qian Li²  Xuan Liu²  Yun Huang²  Tao Tang²  Saijing Zheng¹  Weimiao Wang¹  Jintian Tang² 

[1] Shanghai Tobacco Group Corporation, Shanghai 200082, China; E-Mails:;Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China; E-Mails:

关键词: Eurotium cristatum;    diketopiperazine;    radical scavenging activity;   

DOI  :  10.3390/molecules191117839

来源: mdpi

【 摘 要 】

A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3), neoechinulin A (4) and variecolorin O (5), were isolated from the crude extract of the fungus Eurotium cristatum. The structure of 1 was elucidated primarily by NMR and MS methods. The absolute configuration of 1 was assigned using Marfey’s method applied to its acid hydrolyzate. Cristatumin F (1) showed modest radical scavenging activity against DPPH radicals, and exhibited marginal attenuation of 3T3L1 pre-adipocytes.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.