Distinct Expression Profiles of Three Melatonin Receptors during Early Development and Metamorphosis in the Flatfish Solea senegalensis

International Journal of Molecular Sciences

Olivier Lan-Chow-Wing⁴  Francesca Confente⁴  Patricia Herrera-Pérez⁴  Esther Isorna³  Olvido Chereguini¹  Maria del Carmen Rendón⁴  Jack Falcón²  José A. Muñoz-Cueto⁴ 

[1] IEO, Spanish Institute of Oceanography, Santander Oceanographic Centre, Promontorio de San Martín, s/n, P.O. Box 240, E-39080 Santander, Spain; E-Mail:;Aragó Laboratory—UMR7628 (CNRS and UPMC) and GDR2821 (CNRS/Ifremer), F-66651 Banyuls/Mer, France; E-Mail:;Department of Physiology (Animal Physiology II), Faculty of Biology, Complutense University of Madrid, E-28040 Madrid, Spain; E-Mail:;Department of Biology, Faculty of Marine and Environmental Sciences, University of Cádiz, Marine Campus of International Excellence (CEIMAR), Agrifood Campus of International Excellence (ceiA3), E-11510 Puerto Real, Spain; E-Mails:

关键词: melatonin receptors;    development;    metamorphosis;    flatfish;   

DOI  :  10.3390/ijms151120789

来源: mdpi

【 摘 要 】

Melatonin actions are mediated through G protein-coupled transmembrane receptors. Recently, mt1, mt2, and mel1c melatonin receptors were cloned in the Senegalese sole. Here, their day-night and developmental expressions were analyzed by quantitative PCR. These results revealed distinct expression patterns of each receptor through development. mel1c transcripts were more abundant in unfertilized ovulated oocytes and declined during embryonic development. mt1 and mt2 expression was higher at the earliest stages (2–6 days post-fertilization), decreasing before (mt2) or during (mt1) metamorphosis. Only mt1 and mel1c expression exhibited day-night variations, with higher nocturnal mRNA levels. These results suggest different roles and transcriptional regulation of these melatonin receptors during flatfish development and metamorphosis.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.