Effects of the Continuous Administration of an Agaricus blazei Extract to Rats on Oxidative Parameters of the Brain and Liver during Aging

Molecules

Anacharis B. de Sá-Nakanishi²  Andréia A. Soares²  Maria R. M. Natali¹  Jurandir Fernando Comar²  Rosane M. Peralta²  Adelar Bracht² 

[1]Department of Morphological Sciences, State University of Maringá, 87020900 Maringá, Brazil

[2] E-Mail:

[3]Department of Biochemistry, State University of Maringá, 87020900 Maringá, Brazil

[4] E-Mails:

关键词: aging;    oxidative stress;    oxidative damage;    brain;    liver;    A. blazei treatment;   

DOI  :  10.3390/molecules191118590

来源: mdpi

【 摘 要 】

An investigation of the effects of an aqueous extract of Agaricus blazei, a medicinal mushroom, on the oxidative state of the brain and liver of rats during aging (7 to 23 months) was conducted. The treatment consisted in the daily intragastric administration of 50 mg/kg of the extract. The A. blazei treatment tended to maintain the ROS contents of the brain and liver at lower levels, but a significant difference was found only at the age of 23 months and in the brain. The TBARS levels in the brain were maintained at lower levels by the A. blazei treatment during the whole aging process with a specially pronounced difference at the age of 12 months. The total antioxidant capacity in the brain was higher in treated rats only at the age of 12 months. Compared with previous studies in which old rats (21 months) were treated during a short period of 21 days with 200 mg/kg, the effects of the A. blazei extract in the present study tended to be less pronounced. The results also indicate that the long and constant treatment presented a tendency of becoming less effective at ages above 12 months.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.