International Journal of Molecular Sciences | |
Plasma Levels of Homocysteine and Cysteine Increased in Pediatric NAFLD and Strongly Correlated with Severity of Liver Damage | |
Anna Pastore1  Anna Alisi2  Giannadi Giovamberardino1  Annalisa Crudele2  Sara Ceccarelli2  Nadia Panera2  Carlo Dionisi-Vici1  Valerio Nobili2  | |
[1] Metabolomics and Proteomics Unit, “Bambino Gesù” Children’s Hospital, IRCCS, Rome 00165, Italy; E-Mails:;Liver Research Unit, “Bambino Gesù” Children’s Hospital, IRCCS, Rome 00165, Italy; E-Mails: | |
关键词: homocysteine; cysteine; cysteinylglycine; glutathione; non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); | |
DOI : 10.3390/ijms151121202 | |
来源: mdpi | |
【 摘 要 】
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of metabolic abnormalities ranging from simple triglyceride accumulation in the hepatocytes to hepatic steatosis with inflammation, ballooning and fibrosis. It has been demonstrated that the pathogenesis of NAFLD involves increased oxidative stress, with consumption of the major cellular antioxidant, glutathione (GSH). Liver has a fundamental role in sulfur compound metabolism, although the data reported on plasma thiols status in NAFLD are conflicting. We recruited 63 NAFLD patients, and we analyzed all plasma thiols, such as homocysteine (Hcy), cysteine (Cys), cysteinylglycine (CysGly) and GSH, by high-performance liquid chromatography (HPLC) with fluorescence detection. Hcy, Cys and CysGly plasma levels increased in NAFLD patients (
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190019712ZK.pdf | 1910KB | download |