Antioxidant and Antifatigue Activities of Polygonatum Alte-lobatum Hayata Rhizomes in Rats

Nutrients

Chi-Ting Horng³  Jon-Kway Huang²  Hui-Yun Wang²  Chi-Chang Huang¹ 

[1] Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan;Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 90741, Taiwan; E-Mails:;Department of Ophthalmology and Medical Education Center, Kaohsiung Armed Force General Hospital, Kaohsiung 80284, Taiwan; E-Mail:

关键词: Polygonatum alte-lobatum Hayata;    antioxidant;    anti-fatigue;    biochemical parameters;    exercised rats;   

DOI  :  10.3390/nu6115327

来源: mdpi

【 摘 要 】

Polygonatum alte-lobatum Hayata, a rhizomatous perennial herb, belongs to the Liliaceae family and is endemic to Taiwan. We investigated the antioxidant and anti-fatigue activities of P. alte-lobatum in exercised rats. Levels of polyphenols, flavonoids and polysaccharides and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity were measured in extracts of P. alte-lobatum (EPA). Sprague-Dawley rats were randomly divided into four groups for 8-week treatment with vehicle (control) and low-, medium-, and high-dose EPA (LEPA, MEPA, HEPA; 0, 75, 150, and 375 mg/kg/day, respectively). Exercise performance was evaluated by exhaustive treadmill exercise time and by changes in body composition and biochemical variables at the end of the experiment. EPA contained polyphenols, flavonoids and polysaccharides, with polysaccharide content at least 26 times greater than that of polyphenols and flavonoids. Trend analysis revealed that EPA dose-dependently scavenged DPPH free radicals. EPA treatment dose-dependently increased endurance running time to exhaustion and superoxide dismutase activity and total antioxidant ability of blood. EPA dose-dependently decreased serum urea nitrogen and malondialdehyde levels after exercise. Hepatic glycogen content, an important energy source for exercise, was significantly increased with EPA treatment. EPA could be a potential agent with an anti-fatigue pharmacological function.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.