Nomenclature- and Database-Compatible Names for the Two Ebola Virus Variants that Emerged in Guinea and the Democratic Republic of the Congo in 2014

Viruses

Jens H. Kuhn²  Kristian G. Andersen¹¹  Sylvain Baize⁶  Yīmíng Bào¹²  Sina Bavari¹⁰  Nicolas Berthet¹³  Olga Blinkova¹²  J. Rodney Brister¹²  Anna N. Clawson²  Joseph Fair⁸  Martin Gabriel²⁰  Robert F. Garry⁴  Stephen K. Gire¹¹  Augustine Goba^2,17  Jean-Paul Gonzalez^2,9  Stephan Günther²⁰  Christian T. Happi^2,7  Peter B. Jahrling²  Jimmy Kapetshi^2,15  Gary Kobinger^2,16  Jeffrey R. Kugelman¹⁰  Eric M. Leroy¹³  Gael Darren Maganga¹³  Placide K. Mbala^2,15  Lina M. Moses⁴  Jean-Jacques Muyembe-Tamfum^2,15  Magassouba N�ly^2,22  Stuart T. Nichol^2,21  Sunday A. Omilabu^2,19  Gustavo Palacios¹⁰  Daniel J. Park^1,2  Janusz T. Paweska^2,14  Sheli R. Radoshitzky¹⁰  Cynthia A. Rossi¹⁰  Pardis C. Sabeti¹¹  John S. Schieffelin⁴  Randal J. Schoepp¹⁰  Rachel Sealfon^5,11  Robert Swanepoel^3,11  Jonathan S. Towner^2,21  Jiro Wada²  Nadia Wauquier^2,9  Nathan L. Yozwiak¹¹  Pierre Formenty^11,18 

[1] The Broad Institute, Cambridge, MA 02142, USA; E-Mail:;Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA; E-Mails:;Zoonoses Research Unit, University of Pretoria, Private bag X20 Hatfield, Pretoria 0028, South Africa; E-Mail:;Tulane University School of Medicine, New Orleans, LA 70112, USA; E-Mails:;Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; E-Mail:;Unité de Biologie des Infections Virales Emergentes, Institut Pasteur, Lyon, France; Centre International de Recherche en Infectiologie (CIRI), Université de Lyon, INSERM U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, CNRS UMR5308, Lyon, France; E-Mail:;Department of Biological Sciences, College of Natural Sciences, and African Centre of Excellence for Genomics of Infectious Diseases, Redeemer’s University, Mowe, Ogun State, Nigeria; E-Mail:;Fondation Mérieux, Washington, DC 20036, USA; E-Mail:;Metabiota, Inc., San Francisco, CA 94104, USA; E-Mails:;United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA; E-Mails:;FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA; E-Mails:;Information Engineering Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA; E-Mails:;Centre International de Recherches Médicales de Franceville, B. P. 769, Franceville, Gabon; E-Mails:;Center for Emerging and Zoonotic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham-Johannesburg 2192, Gauteng, South Africa; E-Mail:;Institut National de Recherche Biomédicales, Kinshasa-Gombe BP 1197, Republic of the Congo; E-Mails:;Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; E-Mail:;Kenema Government Hospital, Kenema, Sierra Leone; E-Mail:;World Health Organization, 1211 Geneva, Switzerland; E-Mail:;Department of Medical Microbiology and Parasitology, College of Medicine of the University of Lagos, Idi-Araba, Private Mail Bag 12003, Lagos, Nigeria; E-Mail:;Bernhard Nocht Institute for Tropical Medicine, World Health Organization (WHO) Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, and the German Center for Infection Research (DZIF), Partner Site Hamburg, 20259 Hamburg, Germany; E-Mails:;Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA; E-Mails:;Université Gamal Abdel Nasser de Conakry, Laboratoire des fièvres hémorragiques en Guinée, Hôpital National Donka, Service des Maladies Infectieuses et Tropicales, BP 5680, Conakry, Guinea; E-Mail:

关键词: Ebola;    Ebola virus;    ebolavirus;    filovirid;    Filoviridae;    filovirus;    genome annotation;    Lomela;    Lokolia;    Makona;    mononegavirad;    Mononegavirales;    mononegavirus;    virus classification;    virus isolate;    virus nomenclature;    virus strain;    virus taxonomy;    virus variant;   

DOI  :  10.3390/v6114760

来源: mdpi

【 摘 要 】

In 2014, Ebola virus (EBOV) was identified as the etiological agent of a large and still expanding outbreak of Ebola virus disease (EVD) in West Africa and a much more confined EVD outbreak in Middle Africa. Epidemiological and evolutionary analyses confirmed that all cases of both outbreaks are connected to a single introduction each of EBOV into human populations and that both outbreaks are not directly connected. Coding-complete genomic sequence analyses of isolates revealed that the two outbreaks were caused by two novel EBOV variants, and initial clinical observations suggest that neither of them should be considered strains. Here we present consensus decisions on naming for both variants (West Africa: “Makona”, Middle Africa: “Lomela”) and provide database-compatible full, shortened, and abbreviated names that are in line with recently established filovirus sub-species nomenclatures.

【 授权许可】

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.