Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity

Molecules

Juan David Guzman¹ 

[1] Departamento de Química y Biología, División de Ciencias Básicas, Universidad del Norte, Km. 5 vía Puerto Colombia, Barranquilla 081007, Colombia; E-Mail

关键词: cinnamic acid;    coumaric acids;    hybrids;    antimicrobial;    tuberculosis;   

DOI  :  10.3390/molecules191219292

来源: mdpi

【 摘 要 】

Antimicrobial natural preparations involving cinnamon, storax and propolis have been long used topically for treating infections. Cinnamic acids and related molecules are partly responsible for the therapeutic effects observed in these preparations. Most of the cinnamic acids, their esters, amides, aldehydes and alcohols, show significant growth inhibition against one or several bacterial and fungal species. Of particular interest is the potent antitubercular activity observed for some of these cinnamic derivatives, which may be amenable as future drugs for treating tuberculosis. This review intends to summarize the literature data on the antimicrobial activity of the natural cinnamic acids and related derivatives. In addition, selected hybrids between cinnamic acids and biologically active scaffolds with antimicrobial activity were also included. A comprehensive literature search was performed collating the minimum inhibitory concentration (MIC) of each cinnamic acid or derivative against the reported microorganisms. The MIC data allows the relative comparison between series of molecules and the derivation of structure-activity relationships.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.