Polylactide Conjugates of Camptothecin with Different Drug Release Abilities

Molecules

Ewa Oledzka³  Paweł Horeglad⁴  Zuzanna Gruszczyńska³  Andrzej Plichta²  Grzegorz Nałᆜz-Jawecki¹  Marcin Sobczak³ 

[1] Department of Environmental Health Science, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland; E-Mail:;Chair of Polymer Chemistry and Technology, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland; E-Mail:;Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland; E-Mails:;Centre of New Technologies, University of Warsaw, Banacha 2c, Warsaw 02-097, Poland; E-Mail:

关键词: macromolecular conjugates;    biodegradable polymers;    camptothecin;    drug delivery systems;    controlled release;   

DOI  :  10.3390/molecules191219460

来源: mdpi

【 摘 要 】

Camptothecin-polylactide conjugates (CMPT-PLA) were synthesized by covalent incorporation of CMPT into PLA of different microstructure, i.e., atactic PLA and atactic-block-isotactically enriched PLA (P_m = 0.79) via urethane bonds. The kinetic release of CPMT from CMPT-PLA conjugates, tested in vitro under different conditions, is possible in both cases and notably, strongly dependent on PLA microstructure. It shows that release properties of drug-PLA conjugates can be tailored by controlled design of the PLA microstructure, and allow in the case of CMPT-PLA conjugates for the development of highly controlled biodegradable CMPT systems—important delivery systems for anti-cancer agents.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.