Anti-Cholinesterase Activity of Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis

Molecules

Nguyen Ngoc Chuong²  Nguyen Thi Thu Huong²  Tran Manh Hung¹  Tran Cong Luan² 

[1] Faculty of Chemistry, University of Science, Vietnam National University-HoChiMinh City, 227 Nguyen Van Cu, District 5, Ho Chi Minh City 227-01, Vietnam;Research Center of Ginseng and Medicinal Materials, 41 Dinh Tien Hoang, District 1, Ho Chi Minh City 700-00, Vietnam

关键词: Huperzia squarrosa;    Lycopodiaceae;    lycosquarosine A;    acetylcholinesterase;    Lycopodium alkaloids;   

DOI  :  10.3390/molecules191119172

来源: mdpi

【 摘 要 】

A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8α-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa. Among them, lycosquarosine A (1) is the new metabolite of the natural source. Lycosquarosine A completely inhibited AChE activity in a dose dependent manner with an IC₅₀ value of 54.3 μg/mL, while acetylaposerratinine (2) showed stronger inhibitory activity than 1 with an IC₅₀ value of 15.2 µg/mL. This result indicates that these alkaloids may be a potent source of AChE inhibitors.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.