Glycerophosphate/Acylglycerophosphate Acyltransferases

Biology

Atsushi Yamashita¹  Yasuhiro Hayashi²  Naoki Matsumoto²  Yoko Nemoto-Sasaki²  Saori Oka²  Takashi Tanikawa²  Takayuki Sugiura² 

[1] Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan;

关键词: acyltransferase;    acyl-CoA;    triacylglycerol;    phospholipid;    GPAT;    AGPAT;   

DOI  :  10.3390/biology3040801

来源: mdpi

【 摘 要 】

Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol (TAG) and glycerophospholipids. Many enzymes belonging to the GPAT/AGPAT family have recently been identified and their physiological or pathophysiological roles have been proposed. The roles of GPAT/AGPAT in the synthesis of TAG and obesity-related diseases were revealed through the identification of causative genes of these diseases or analyses of genetically manipulated animals. Recent studies have suggested that some isoforms of GPAT/AGPAT family enzymes are involved in the fatty acid remodeling of phospholipids. The enzymology of GPAT/AGPAT and their physiological/pathological roles in the metabolism of glycerolipids have been described and discussed in this review.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.