Cytotoxicity Evaluation of a New Set of 2-Aminobenzo[de]iso-quinoline-1,3-diones

International Journal of Molecular Sciences

Rashad Al-Salahi¹  Ibrahim Alswaidan¹  Mohamed Marzouk¹ 

[1] Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; E-Mails:

关键词: cytotoxicity;    HCT-116;    Hep-G2;    aminobenzo[de]isoquinoline-1;    3-diones;    doxorubicin;   

DOI  :  10.3390/ijms151222483

来源: mdpi

【 摘 要 】

A new series of 2-amino-benzo[de]isoquinoline-1,3-diones was synthesized and fully characterized in our previous paper. Here, their cytotoxic effects have been evaluated in vitro in relation to colon HCT-116, hepatocellular Hep-G2 and breast MCF-7 cancer cell lines, using a crystal violet viability assay. The IC₅₀-values of the target compounds are reported in µg/mL, using doxorubicin as a reference drug. The findings revealed that compounds 14, 15, 16, 21 and 22 had significant cytotoxic effects against HCT-116, MCF-7 and Hep-G2 cell lines. Their IC₅₀ values ranged between 1.3 and 8.3 μg/mL in relation to doxorubicin (IC₅₀ ≈ 0.45–0.89 μg/mL). Therefore, these compounds could be used as templates for furthering the development and design of more potent antitumor agents through structural modification.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.