Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin

Molecules

Zong-Bo Xie¹  Da-Zhao Sun¹  Guo-Fang Jiang²  Zhang-Gao Le¹ 

[1] Department of Applied Chemistry, East China Institute of Technology, Nanchang 330013, China;

关键词: bis(indolyl)methanes;    tandem protocol;    biocatalysis;    promiscuity;    α-chymotrypsin;   

DOI  :  10.3390/molecules191219665

来源: mdpi

【 摘 要 】

A mild and efficient method catalyzed by α-chymotrypsin was developed for the synthesis of bis(indolyl)methanes through a cascade process between indole and aromatic aldehydes. In the ethanol aqueous solution, a green medium, a wide range of aromatic aldehydes could react with indole to afford the desired products with moderate to good yields (from 68% to 95%) using a little α-chymotrypsin as catalyst.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.