Molecular Actions of Ovarian Cancer G Protein-Coupled Receptor 1 Caused by Extracellular Acidification in Bone

International Journal of Molecular Sciences

Feng-Lai Yuan¹  Ming-Dong Zhao¹  Li-Bo Jiang¹  Hui-Ren Wang¹  Lu Cao¹  Xiao-Gang Zhou¹  Xi-Lei Li¹  Jian Dong¹ 

[1] Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China; E-Mails:

关键词: extracellular acidification;    OGR1;    osteoclasts;    osteoblasts;    endplate chondrocytes;   

DOI  :  10.3390/ijms151222365

来源: mdpi

【 摘 要 】

Extracellular acidification occurs under physiologic and pathologic conditions, such as exercise, ischemia, and inflammation. It has been shown that acidosis has various adverse effects on bone. In recent years there has been increasing evidence which indicates that ovarian cancer G protein-coupled receptor 1 (OGR1) is a pH-sensing receptor and mediates a variety of extracellular acidification-induced actions on bone cells and other cell types. Recent studies have shown that OGR1 is involved in the regulation of osteoclast differentiation, survival, and function, as well as osteoblast differentiation and bone formation. Moreover, OGR1 also regulates acid-induced apoptosis of endplate chondrocytes in intervertebral discs. These observations demonstrate the importance of OGR1 in skeletal development and metabolism. Here, we provide an overview of OGR1 regulation ofosteoclasts, osteoblasts, and chondrocytes, and the molecular actions of OGR1 induced by extracellular acidification in the maintenance of bone health.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.