Two New Coumarins from Talaromyces flavus

Molecules

Jun-Wei He²  Da-Peng Qin²  Hao Gao²  Run-Qiao Kuang²  Yang Yu²  Xing-Zhong Liu¹  Xin-Sheng Yao² 

[1] State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China;Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China

关键词: Talaromyces flavus;    coumarin;    structure elucidation;    biological activities;   

DOI  :  10.3390/molecules191220880

来源: mdpi

【 摘 要 】

Two new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12in 1 was assigned using the modified Mosher’s method, whereas that of C-12in 2 was deduced via the circular dichroism data of its corresponding [Rh₂(OCOCF₃)₄] complex. Compounds 1 and 2 were evaluated for their anti-Aβ₄₂ aggregation, cytotoxic, and antimicrobial activities. The results showed that the two compounds had moderate anti-Aβ₄₂ aggregation activity, and this is the first report on the Aβ₄₂ inhibitory aggregation activity of coumarins.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.