Four New Furostanol Saponins from the Rhizomes and Roots of Smilax scobinicaulis and Their Cytotoxicity

Molecules

Jing Xu²  Shixiu Feng¹  Qi Wang²  Yingli Cao²  Miao Sun²  Cunli Zhang² 

[1] Key Laboratory of Southern Subtropical Plant Diversity, Shenzhen Fairy Lake Botanical Garden, Chinese Academy of Sciences, 160 Xianhu Road, Liantang, Shenzhen 518004, China; E-Mail:;College of Life Science, Northwest A&F University, Yangling 712100, Shaanxi, China; E-Mails:

关键词: Smilax scobinicaulis;    furostanol saponins;    cytotoxic activity;   

DOI  :  10.3390/molecules191220975

来源: mdpi

【 摘 要 】

Four new furostanol saponins 1–4, along with two known furostanol saponins 5 and 6 and one known spirostanol saponin 7 were isolated from the rhizomes and roots of Smilax scobinicaulis. The structures of the new saponins were elucidated as 26-O-β-d-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-22-methoxyl-6-one-3-O-α-l-arabinopyranosyl-(1→6)-β-d-glucopyranoside (1), 26-O-β-d-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-22-methoxyl-6-one (2), 26-O-β-d-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-20(22)-en-6-one (3), 26-O-β-d-glucopyranoside-3β,23,26-trihydroxy-(23R, 25R)-5α-furostan-20(22)-en-6-one (4) on the basis of spectroscopic analysis. The isolated saponins were evaluated for cytotoxic activity against two human cancer cell lines including Hela (cervical carcinoma) and SMMC-7221 (hepatocellular carcinoma). Compounds 1 and 7 demonstrated cytotoxicity against the tested cell lines.

【 授权许可】

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