Immunoglobulins: 25 Years of Immunoinformatics and IMGT-ONTOLOGY

Biomolecules

关键词: IMGT;    immunogenetics;    immunoinformatics;    IMGT-ONTOLOGY;    IMGT Collier de Perles;    immunoglobulin;    immune repertoire;    IMGT unique numbering;    next generation sequencing;    antibody humanization;   

DOI  :  10.3390/biom4041102

来源: mdpi

【 摘 要 】

IMGT^®, the international ImMunoGeneTics information system^® (CNRS and Montpellier University) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989, IMGT^® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT^® is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH), and IgSF and MhSF superfamilies. IMGT^® has been built on the IMGT-ONTOLOGY axioms and concepts, which bridged the gap between genes, sequences and three-dimensional (3D) structures. The concepts include the IMGT^® standardized keywords (identification), IMGT^® standardized labels (description), IMGT^® standardized nomenclature (classification), IMGT unique numbering and IMGT Colliers de Perles (numerotation). IMGT^® comprises seven databases, 15,000 pages of web resources and 17 tools. IMGT^® tools and databases provide a high-quality analysis of the IG from fish to humans, for basic, veterinary and medical research, and for antibody engineering and humanization. They include, as examples: IMGT/V-QUEST and IMGT/JunctionAnalysis for nucleotide sequence analysis and their high-throughput version IMGT/HighV-QUEST for next generation sequencing, IMGT/DomainGapAlign for amino acid sequence analysis of IG domains, IMGT/3Dstructure-DB for 3D structures, contact analysis and paratope/epitope interactions of IG/antigen complexes, and the IMGT/mAb-DB interface for therapeutic antibodies and fusion proteins for immunological applications (FPIA).

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.