International Journal of Molecular Sciences | |
Docetaxel-Encapsulating Small-Sized Polymeric Micelles with Higher Permeability and Its Efficacy on the Orthotopic Transplantation Model of Pancreatic Ductal Adenocarcinoma | |
Yunfei Li1  Peiran Li2  Mingji Jin1  Changgao Jiang2  Zhonggao Gao1  | |
[1] State Key Laboratory of Bioactive Substance and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100050, China; E-Mails:;Surgical Department, the Affiliated Hospital of Yanbian University, Yanji 133000, China; E-Mail: | |
关键词: pancreatic ductal adenocarcinoma; small-sized polymeric micelles; docetaxel; permeability; orthotopic transplantation model; | |
DOI : 10.3390/ijms151223571 | |
来源: mdpi | |
【 摘 要 】
Pancreatic ductal adenocarcinoma (PDAC) elicits a dense stromal response that blocks vascular access because of pericyte coverage of vascular fenestrations. In this way, the PDAC stroma contributes to chemotherapy resistance, and the small-sized nanocarrier loaded with platinum has been adopted to address this problem which is not suitable for loading docetaxel (DTX). In the present study, we used the poly(
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
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