Glycol Chitosan-Based Fluorescent Theranostic Nanoagents for Cancer Therapy

Marine Drugs

Jin-Kyu Rhee²  Ok Kyu Park³  Aeju Lee¹  Dae Hyeok Yang⁴  Kyeongsoon Park³ 

[1] Biomedical Research Center, Korea Institute of Science and Technology, Seoul 136-791, Korea; E-Mail:;Western Seoul Center, Korea Basic Science Institute, Seoul 120-140, Korea; E-Mail:;Division of Bio-imaging, Chuncheon Center, Korea Basic Science Institute, Gangwon-do 200-701, Korea; E-Mail:;Institute of Cell & Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea

关键词: glycol chitosan;    theranostics;    nanosystem;    fluorescence;    cancer;   

DOI  :  10.3390/md12126038

来源: mdpi

【 摘 要 】

Theranostics is an integrated nanosystem that combines therapeutics with diagnostics in attempt to develop new personalized treatments with enhanced therapeutic efficacy and safety. As a promising therapeutic paradigm with cutting-edge technologies, theranostic agents are able to simultaneously deliver therapeutic drugs and diagnostic imaging agents and also monitor the response to therapy. Polymeric nanosystems have been intensively explored for biomedical applications to diagnose and treat various cancers. In recent years, glycol chitosan-based nanoagents have been developed as dual-purpose materials for simultaneous diagnosis and therapy. They have shown great potential in cancer therapies, such as chemotherapeutics and nucleic acid and photodynamic therapies. In this review, we summarize the recent progress and potential applications of glycol chitosan-based fluorescent theranostic nanoagents for cancer treatments and discuss their possible underlying mechanisms.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.