Territrem and Butyrolactone Derivatives from a Marine-Derived Fungus Aspergillus Terreus

Marine Drugs

Xu-Hua Nong¹  Yi-Fei Wang²  Xiao-Yong Zhang¹  Mu-Ping Zhou²  Xin-Ya Xu¹  Shu-Hua Qi¹ 

[1] CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301 Guangdong, China; E-Mails:;Jinan University, 601 West Huangpu Road, Guangzhou, 510632 Guangdong, China; E-Mails:

关键词: Aspergillus terreus;    anti-acetylcholinesterase;    anti-HSV-1;    antifouling;    butyrolactone derivative;    territrem derivative;   

DOI  :  10.3390/md12126113

来源: mdpi

【 摘 要 】

Seventeen lactones including eight territrem derivatives (1–8) and nine butyrolactone derivatives (9–17) were isolated from a marine-derived fungus Aspergillus terreus SCSGAF0162 under solid-state fermentation of rice. Compounds 1–3 and 9–10 were new, and their structures were elucidated by spectroscopic analysis. The acetylcholinesterase inhibitory activity and antiviral activity of compounds 1–17 were evaluated. Among them, compounds 1 and 2 showed strong inhibitory activity against acetylcholinesterase with IC₅₀ values of 4.2 ± 0.6, 4.5 ± 0.6 nM, respectively. This is the first time it has been reported that 3, 6, 10, 12 had evident antiviral activity towards HSV-1 with IC₅₀ values of 16.4 ± 0.6, 6.34 ± 0.4, 21.8 ± 0.8 and 28.9 ± 0.8 μg·mL⁻¹, respectively. Antifouling bioassay tests showed that compounds 1, 11, 12, 15 had potent antifouling activity with EC₅₀ values of 12.9 ± 0.5, 22.1 ± 0.8, 7.4 ± 0.6, 16.1 ± 0.6 μg·mL⁻¹ toward barnacle Balanus amphitrite larvae, respectively.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.