Emerging Regulation and Function of Betatrophin

International Journal of Molecular Sciences

Yi-Hsin Tseng¹  Yung-Hsin Yeh²  Wei-Jan Chen²  Kwang-Huei Lin¹ 

[1] Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan; E-Mail:;First Cardiovascular Division, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan; E-Mails:

关键词: betatrophin;    C19orf80;    chromosome 19 open reading frame 80;    RIFL;    lipasin;    ANGPTL8;    TD26;    thyroid hormone;    irisin;    insulin and lipid;   

DOI  :  10.3390/ijms151223640

来源: mdpi

【 摘 要 】

Betatrophin, also known as TD26/RIFL/lipasin/ANGPTL8/C19orf80, is a novel protein predominantly expressed in human liver. To date, several betatrophin orthologs have been identified in mammals. Increasing evidence has revealed an association between betatrophin expression and serum lipid profiles, particularly in patients with obesity or diabetes. Stimulators of betatrophin, such as insulin, thyroid hormone, irisin and caloric intake, are usually relevant to energy expenditure or thermogenesis. In murine models, serum triglyceride levels as well as pancreatic cell proliferation are potently enhanced by betatrophin. Intriguingly, conflicting phenomena have also been reported that betatrophin suppresses hepatic triglyceride levels, suggesting that betatrophin function is mediated by complex regulatory processes. However, its precise physiological role remains unclear at present. In this review, we have summarized the current findings on betatrophin and their implications.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.