P2X and P2Y Receptors—Role in the Pathophysiology of the Nervous System

International Journal of Molecular Sciences

Kamila Puchałowicz²  Maciej Tarnowski¹  Irena Baranowska-Bosiacka²  Dariusz Chlubek²  Violetta Dziedziejko² 

[1] Department of Physiology, Pomeranian Medical University, 72 Powstańców Wielkopolskich Street, Szczecin 70-111, Poland; E-Mail:;Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 72 Powstańców Wielkopolskich Street, Szczecin 70-111, Poland; E-Mails:

关键词: Alzheimer’s disease;    ATP;    depression;    epilepsy;    glioma;    multiple sclerosis;    neurodegenerative disease;    neuropathic pain;    P2X receptors;    P2Y receptors;   

DOI  :  10.3390/ijms151223672

来源: mdpi

【 摘 要 】

Purinergic signalling plays a crucial role in proper functioning of the nervous system. Mechanisms depending on extracellular nucleotides and their P2 receptors also underlie a number of nervous system dysfunctions. This review aims to present the role of purinergic signalling, with particular focus devoted to role of P2 family receptors, in epilepsy, depression, neuropathic pain, nervous system neoplasms, such as glioma and neuroblastoma, neurodegenerative diseases like Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. The above-mentioned conditions are associated with changes in expression of extracellular ectonucleotidases, P2X and P2Y receptors in neurons and glial cells, as well as releasing considerable amounts of nucleotides from activated or damaged nervous tissue cells into the extracellular space, which contributes to disturbance in purinergic signalling. The numerous studies indicate a potential possibility of using synthetic agonists/antagonists of P2 receptors in treatment of selected nervous system diseases. This is of particular significance, since numerous available agents reveal a low effectiveness and often produce side effects.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.