Toxins | |
Triggering of Programmed Erythrocyte Death by Alantolactone | |
Kousi Alzoubi2  Salvatrice Calabrò2  Jasmin Egler2  Caterina Faggio1  Florian Lang2  | |
[1] Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres 31, 98166 S. Agata-Messina, Italy; E-Mail:;Department of Physiology, University of Tübingen, Gmelinstr. 5, 72076 Tuebingen, Germany; E-Mails: | |
关键词: phosphatidylserine; alantolactone; ceramide; oxidative stress; cell volume; eryptosis; | |
DOI : 10.3390/toxins6123596 | |
来源: mdpi | |
【 摘 要 】
The sesquiterpene alantolactone counteracts malignancy, an effect at least in part due to stimulation of suicidal death or apoptosis of tumor cells. Signaling of alantolactone induced apoptosis involves altered gene expression and mitochondrial depolarization. Erythrocytes lack mitochondria and nuclei but may enter suicidal death or eryptosis, which is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine exposure at the erythrocyte surface. Cellular mechanisms involved in triggering of eryptosis include increase of cytosolic Ca2+-activity ([Ca2+]
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190018291ZK.pdf | 524KB | download |