Enzymatic Polymerization of Cyclic Monomers in Ionic Liquids as a Prospective Synthesis Method for Polyesters Used in Drug Delivery Systems

Molecules

Urszula Piotrowska¹  Marcin Sobczak¹ 

[1] Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland; E-Mail:

关键词: biomedical polymers;    macromolecular conjugates of drugs;    enzymatic ring opening polymerization;    ionic liquids;    biodegradable polyesters;    drug delivery systems;   

DOI  :  10.3390/molecules20010001

来源: mdpi

【 摘 要 】

Biodegradable or bioresorbable polymers are commonly used in various pharmaceutical fields (e.g., as drug delivery systems, therapeutic systems or macromolecular drug conjugates). Polyesters are an important class of polymers widely utilized in pharmacy due to their biodegradability and biocompatibility features. In recent years, there has been increased interest in enzyme-catalyzed ring-opening polymerization (e-ROP) of cyclic esters as an alternative method of preparation of biodegradable or bioresorbable polymers. Ionic liquids (ILs) have been presented as green solvents in enzymatic ring-opening polymerization. The activity, stability, selectivity of enzymes in ILs and the ability to catalyze polyester synthesis under these conditions are discussed. Overall, the review demonstrates that e-ROP of lactones or lactides could be an effective method for the synthesis of useful biomedical polymers.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.