Molecules | |
Eliminating the Heart from the Curcumin Molecule: Monocarbonyl Curcumin Mimics (MACs) | |
Dinesh Shetty4  Yong Joon Kim2  Hyunsuk Shim3  James P. Snyder2  Bharat B. Aggarwal1  | |
[1] Center for Self–assembly and Complexity, Institute for Basic Science, Pohang 790-784, Korea; E-Mail;Department of Chemistry, Emory University, Atlanta, GA 30322, USA; E-Mail:;Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA; E-Mail:;Center for Self–assembly and Complexity, Institute for Basic Science, Pohang 790-784, Korea; E-Mail: | |
关键词: monocarbonyl analogs of curcumin; MACs; inflammation; cancer; infectious disease; anti-angiogenesis; NF-κB; TNF-α; | |
DOI : 10.3390/molecules20010249 | |
来源: mdpi | |
【 摘 要 】
Curcumin is a natural product with several thousand years of heritage. Its traditional Asian application to human ailments has been subjected in recent decades to worldwide pharmacological, biochemical and clinical investigations. Curcumin’s Achilles heel lies in its poor aqueous solubility and rapid degradation at pH ~ 7.4. Researchers have sought to unlock curcumin’s assets by chemical manipulation. One class of molecules under scrutiny are the monocarbonyl analogs of curcumin (MACs). A thousand plus such agents have been created and tested primarily against cancer and inflammation. The outcome is clear.
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190018162ZK.pdf | 1461KB | download |