Genes | |
Down-Regulation of miR-129-5p and the let-7 Family in Neuroendocrine Tumors and Metastases Leads to Up-Regulation of Their Targets Egr1, G3bp1, Hmga2 and Bach1 | |
Kristina B. V. Døssing3  Tina Binderup5  Bogumil Kaczkowski6  Anders Jacobsen6  Maria Rossing3  Ole Winther4  Birgitte Federspiel1  Ulrich Knigge2  Andreas Kjær5  Lennart Friis-Hansen3  | |
[1]Department of Pathology, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark | |
[2] E-Mail: | |
[3]Cluster for Molecular Imaging, Faculty of Health Sciences, Blegdamsvej 3B, 2100 Copenhagen, Denmark | |
[4] E-Mail: | |
[5]Center for Genomic Medicine, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark | |
[6] E-Mails: | |
[7]DTU Informatics, Technical University of Denmark, Anker Engelunds Vej 1, 2800 Kongens Lyngby, Denmark | |
[8] E-Mail: | |
[9]Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark | |
[10] E-Mails: | |
[11]The Bioinformatics Center, Department of Biology and Biotech and Research Innovation Centre, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark | |
[12] E-Mails: | |
关键词: neuroendocrine tumors; cancer; miR-129-5p; let-7; EGR1; G3BP1; HMGA2; BACH1; MMP1; | |
DOI : 10.3390/genes6010001 | |
来源: mdpi | |
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【 摘 要 】
Expression of miRNAs in Neuroendocrine Neoplasms (NEN) is poorly characterized. We therefore wanted to examine the miRNA expression in Neuroendocrine Tumors (NETs), and identify their targets and importance in NET carcinogenesis. miRNA expression in six NEN primary tumors, six NEN metastases and four normal intestinal tissues was characterized using miRNA arrays, and validated by
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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