The Role of Antifungals against Candida Biofilm in Catheter-Related Candidemia

Antibiotics

Emilio Bouza¹  Jesús Guinea¹  Mar໚ Guembe¹ 

[1] Department of Clinical Microbiology and Infectious Diseases, Gregorio Marañón Hospital, Madrid 28007, Spain; E-Mails:

关键词: biofilm;    Candida;    antifungals;    catheter-related candidemia;   

DOI  :  10.3390/antibiotics4010001

来源: mdpi

【 摘 要 】

Catheter-related bloodstream infection (C-RBSI) is one of the most frequent nosocomial infections. It is associated with high rates of morbidity and mortality. Candida spp. is the third most common cause of C-RBSI after coagulase-negative staphylococci and Staphylococcus aureus and is responsible for approximately 8% of episodes. The main cause of catheter-related candidemia is the ability of some Candida strains—mainly C. albicans and C. parapsilosis—to produce biofilms. Many in vitro and in vivo models have been designed to assess the activity of antifungal drugs against Candida biofilms. Echinocandins have proven to be the most active antifungal drugs. Potential options in situations where the catheter cannot be removed include the combination of systemic and lock antifungal therapy. However, well-designed and -executed clinical trials must be performed before firm recommendations can be issued.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.