Mechanisms of Antimicrobial Peptide Resistance in Gram-Negative Bacteria

Antibiotics

Victor I. Band²  David S. Weiss¹ 

[1] Yerkes Primate Research Center, Emory University, Atlanta, GA 30329, USA;Department of Microbiology and Immunology, Emory University, Atlanta, GA 30329, USA; E-Mail:

关键词: antimicrobial peptide;    AMP;    CAMP;    antibiotic resistance;    Gram-negative;   

DOI  :  10.3390/antibiotics4010018

来源: mdpi

【 摘 要 】

Cationic antimicrobial peptides (CAMPs) are important innate immune defenses that inhibit colonization by pathogens and contribute to clearance of infections. Gram-negative bacterial pathogens are a major target, yet many of them have evolved mechanisms to resist these antimicrobials. These resistance mechanisms can be critical contributors to bacterial virulence and are often crucial for survival within the host. Here, we summarize methods used by Gram-negative bacteria to resist CAMPs. Understanding these mechanisms may lead to new therapeutic strategies against pathogens with extensive CAMP resistance.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.