Asperaculanes A and B, Two Sesquiterpenoids from the Fungus Aspergillus aculeatus

Molecules

Yu-Qi Gao²  Chun-Jun Guo¹  Qiang Zhang²  Wen-Ming Zhou²  Clay C. C. Wang¹  Jin-Ming Gao² 

[1] Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA; E-Mail:;Shaanxi Key Laboratory of Natural Products Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China; E-Mails:

关键词: Aspergillus aculeatus;    nordaucane sesquiterpenoids;    ent-daucanes;    natural products;    structure elucidation;   

DOI  :  10.3390/molecules20010325

来源: mdpi

【 摘 要 】

Six sesquiterpenoids 1–6, including two new ones, an ent-daucane-type sesquiterpenoid, asperaculane A (1), and a nordaucane one, asperaculane B (2), and four known nordaucane derivatives, aculenes A–D 3–6, together with the known secalonic acid D (7), were isolated from a fermentation culture of the fungus Aspergillus aculeatus. Their structures and absolute configurations were established by analyses of their spectroscopic data, including 1D and 2D-NMR spectra, HR-ESIMS, electronic circular dichroism (ECD) data, and quantum chemical calculations. These metabolites were evaluated for in vitro cytotoxic activity against two cell lines, human cancer cell lines (HeLa) and one normal hamster cell line (CHO).

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.