International Journal of Molecular Sciences | |
High Levels of KAP1 Expression Are Associated with Aggressive Clinical Features in Ovarian Cancer | |
Yanfen Cui1  Shaobin Yang1  Xin Fu2  Jingwen Feng1  Shilei Xu1  Guoguang Ying1  | |
[1]Laboratory of Cancer Cell Biology, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China | |
[2] E-Mails: | |
[3]Department of Gynecology Cancer, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China | |
[4] E-Mail: | |
关键词: KAP1; ovarian cancer; prognostic factor; | |
DOI : 10.3390/ijms16010363 | |
来源: mdpi | |
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【 摘 要 】
KAP1 is an universal corepressor for Kruppel-associated box zinc finger proteins in both normal and tumor cells. In this study, the biological function and clinical significance of KAP1 expression in ovarian cancer were investigated. Immunohistological staining of KAP1 was evaluated in 111 patients with ovarian epithelial cancer, 15 with ovarian borderline tumor, and 20 normal ovarian tissue. The correlations of KAP1 expression with clinicopathological features were studied. Kaplan-Meier analysis and Cox proportional hazard modeling were used to assess overall survival to analyze the effect of KAP1 expression on the prognosis of ovarian cancer. The positive rates of KAP1 were significantly higher in ovarian epithelial cancer (55.7%) and borderline tumor (20.0%) than in normal ovarian tissue (5.0%) (all
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
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