New Ikarugamycin Derivatives with Antifungal and Antibacterial Properties from Streptomyces zhaozhouensis

Marine Drugs

Rodney Lacret¹  Daniel Oves-Costales²  Cristina Gómez²  Caridad D໚z²  Mercedes de la Cruz²  Ignacio Pérez-Victoria²  Francisca Vicente²  Olga Genilloud²  Fernando Reyes¹ 

[1] Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avda. del Conocimiento 34, Armilla, Granada 18016, Spain;

关键词: Streptomyces zhaozhouensis;    ikarugamycin;    polycyclic tetramate macrolactams;    antifungal;    antibacterial;   

DOI  :  10.3390/md13010128

来源: mdpi

【 摘 要 】

A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1–3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolite ikarugamycin (4). Their structural elucidation was accomplished using a combination of electrospray-time of flight mass spectrometry (ESI-TOF MS) and 1D and 2D NMR analyses. Compounds 1–3 showed antifungal activity against Aspergillus fumigatus, Candida albicans and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.