Ca2+-Dependent Regulations and Signaling in Skeletal Muscle: From Electro-Mechanical Coupling to Adaptation

International Journal of Molecular Sciences

Sebastian Gehlert¹  Wilhelm Bloch²  Frank Suhr¹ 

[1] Institute of Cardiovascular Research and Sport Medicine, Department of Molecular and Cellular Sport Medcine, German Sport University Cologne, Am Sportpark Müngersdorf 6, Cologne 50933, Germany; E-Mail

关键词: calcium;    excitation-contraction coupling;    ryanodine receptor;    sarcoplasmic/endoplasmic reticulumcalcium ATPase;    exercise;    skeletal muscle;    fiber type;    protein turnover;    calcineurin;    peroxisome proliferator-activated receptor γ coactivator 1 α;   

DOI  :  10.3390/ijms16011066

来源: mdpi

【 摘 要 】

Calcium (Ca²⁺) plays a pivotal role in almost all cellular processes and ensures the functionality of an organism. In skeletal muscle fibers, Ca²⁺ is critically involved in the innervation of skeletal muscle fibers that results in the exertion of an action potential along the muscle fiber membrane, the prerequisite for skeletal muscle contraction. Furthermore and among others, Ca²⁺ regulates also intracellular processes, such as myosin-actin cross bridging, protein synthesis, protein degradation and fiber type shifting by the control of Ca²⁺-sensitive proteases and transcription factors, as well as mitochondrial adaptations, plasticity and respiration. These data highlight the overwhelming significance of Ca²⁺ ions for the integrity of skeletal muscle tissue. In this review, we address the major functions of Ca²⁺ ions in adult muscle but also highlight recent findings of critical Ca²⁺-dependent mechanisms essential for skeletal muscle-regulation and maintenance.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.