Hyperlipidemia and Statins Affect Neurological Outcome in Lumbar Spine Injury

International Journal of Environmental Research and Public Health

Wu-Fu Chung⁴  Shih-Wei Liu⁴  Peng-Yuan Chang³  Feng-Shu Lin¹  Li-Fu Chen⁴  Jau-Ching Wu³  Yu-Chun Chen²  Laura Liu⁵  Wen-Cheng Huang³  Henrich Cheng³  Su-Shun Lo² 

[1] Department of Pharmacy, National Yang-Ming University Hospital, I-Lan 260, Taiwan; E-Mail:;School of Medicine, National Yang-Ming University, Taipei 112, Taiwan; E-Mail:;Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei 112, Taiwan; E-Mails:;Department of Emergency Medicine, National Yang-Ming University Hospital, I-Lan 260, Taiwan; E-Mails:;Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan; E-Mail:

关键词: statins;    hyperlipidemia;    lumbar spine injury;    national health insurance;   

DOI  :  10.3390/ijerph120100402

来源: mdpi

【 摘 要 】

The disabling pathophysiologic effects of lipid and neuroprotective effects of statins have recently been demonstrated for acute spinal cord injuries in animal models. This large scale population-based study aimed to investigate the effect hyperlipidemia and the use of statins in patients with lumbar spine injury. The National Health Insurance Research Database of Taiwan was used to identify patients with lumbar spine injury. A total of 2844 patients were grouped into three: no hyperlipidemia, hyperlipidemia using low-dose of statins (≤90 of the defined daily dosage (DDD)), and severe hyperlipidemia using high-dose of statins (>90 DDD). A Cox multiple regression model was used to compare the incidence rates of disability among the three groups. The results showed that patients with hyperlipidemia appeared a higher risk of permanent disability (adjusted HR = 1.38, p = 0.28). In subgroup analysis, patients with severe hyperlipidemia had a higher risk of disability (adjusted HR = 3.1, p < 0.004), whereas hyperlipidemia using low-dose statins had a similar risk of permanently disability (adjusted HR = 0.83, p = 0.661). Hyperlipidemia adversely affected the neurological outcomes of lumbar spinal injury. Statins may have the potential to reverse this higher risk of disability. However, this beneficiary effect of statins only existed in patients using a lower dose (≤90 DDD).

【 授权许可】

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.