Molecules | |
Plasmin Regulation through Allosteric, Sulfated, Small Molecules | |
Rami A. Al-Horani1  Rajesh Karuturi1  Domonique T. White2  Umesh R. Desai2  | |
[1]Department of Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, VA 23219, USA | |
关键词: allosteric inhibitors; library screening; plasmin; sulfated glycosaminoglycan mimetics; | |
DOI : 10.3390/molecules20010608 | |
来源: mdpi | |
![]() |
【 摘 要 】
Plasmin, a key serine protease, plays a major role in clot lysis and extracellular matrix remodeling. Heparin, a natural polydisperse sulfated glycosaminoglycan, is known to allosterically modulate plasmin activity. No small allosteric inhibitor of plasmin has been discovered to date. We screened an
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190017870ZK.pdf | 1465KB | ![]() |