Computational Studies of the Intestinal Host-Microbiota Interactome

Computation

Scott Christley²  Chase Cockrell²  Gary An¹ 

[1] Department of Surgery, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA;

关键词: translational systems biology;    translational bioinformatics;    microbiome;    mathematical modeling and simulation;   

DOI  :  10.3390/computation3010002

来源: mdpi

【 摘 要 】

A large and growing body of research implicates aberrant immune response and compositional shifts of the intestinal microbiota in the pathogenesis of many intestinal disorders. The molecular and physical interaction between the host and the microbiota, known as the host-microbiota interactome, is one of the key drivers in the pathophysiology of many of these disorders. This host-microbiota interactome is a set of dynamic and complex processes, and needs to be treated as a distinct entity and subject for study. Disentangling this complex web of interactions will require novel approaches, using a combination of data-driven bioinformatics with knowledge-driven computational modeling. This review describes the computational approaches for investigating the host-microbiota interactome, with emphasis on the human intestinal tract and innate immunity, and highlights open challenges and existing gaps in the computation methodology for advancing our knowledge about this important facet of human health.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.