Activity of Alkaloids on Peptic Ulcer: What’s New?

Molecules

Raphaela Francelino do Nascimento²  Igor Rafael Praxedes de Sales²  Rodrigo de Oliveira Formiga²  José Maria Barbosa-Filho²  Marianna Vieira Sobral²  Josean Fechine Tavares²  Margareth de Fátima Formiga Melo Diniz²  Leônia Maria Batista¹ 

[1] Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil;

关键词: alkaloids;    gastroprotective;    peptic ulcer;    natural products;    review;   

DOI  :  10.3390/molecules20010929

来源: mdpi

【 摘 要 】

Peptic ulcer is a common disease characterized by lesions that affect the mucosa of the esophagus, stomach and/or duodenum, and may extend into the muscular layer of the mucosa. Natural products have played an important role in the process of development and discovery of new drugs, due to their wide structural diversity and present, mostly specific and selective biological activities. Among natural products the alkaloids, biologically active secondary metabolites, that can be found in plants, animals or microorganisms stand out. The alkaloids are compounds consisting of a basic nitrogen atom that may or may not be part of a heterocyclic ring. This review will describe 15 alkaloids with antiulcer activity in animal models and in vitro studies.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.