Relationship between Expression of Onco-Related miRNAs and the Endoscopic Appearance of Colorectal Tumors

International Journal of Molecular Sciences

Yoshihito Nakagawa²  Yukihiro Akao¹  Kohei Taniguchi¹  Akemi Kamatani²  Tomomitsu Tahara²  Toshiaki Kamano²  Naoko Nakano²  Naruomi Komura²  Hirokazu Ikuno²  Takafumi Ohmori²  Yasutaka Jodai²  Masahiro Miyata²  Mistuo Nagasaka²  Tomoyuki Shibata²  Naoki Ohmiya²  Ichiro Hirata² 

[1]The United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu 501-1193, Japan

[2] E-Mails:

[3]Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Aichi 470-1192, Japan

[4] E-Mails:

关键词: microRNA;    endoscopic appearance;    colorectal tumor;   

DOI  :  10.3390/ijms16011526

来源: mdpi

【 摘 要 】

Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We examined the expression of onco-related miRNAs in 131 sporadic exophytic adenomas or early cancers and in 52 sporadic flat elevated adenomas or early cancers to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. The expression levels of miR-143, -145, and -34a were significantly reduced in most of the exophytic tumors compared with those in the flat elevated ones. In type 2 cancers, the miRNA expression profile was very similar to that of the exophytic tumors. The expression levels of miR-7 and -21 were significantly up-regulated in some flat elevated adenomas compared with those in exophytic adenomas. In contrast, in most of the miR-143 and -145 down-regulated cases of the adenoma-carcinoma sequence and in some of the de novo types of carcinoma, the up-regulation of oncogenic miR-7 and/or -21 contributed to the triggering mechanism leading to the carcinogenetic process. These findings indicated that the expression of onco-related miRNA was associated with the morphological appearance of colorectal tumors.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.