Palladium on Carbon-Catalyzed Suzuki-Miyaura Coupling Reaction Using an Efficient and Continuous Flow System

Catalysts

Tomohiro Hattori²  Aya Tsubone²  Yoshinari Sawama²  Yasunari Monguchi¹  Hironao Sajiki¹ 

[1] Laboratory of Organic Chemistry, Department of Organic and Medicinal Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan;

关键词: flow reaction;    ligand-free;    palladium on carbon;    single-pass;    Suzuki-Miyaura coupling;   

DOI  :  10.3390/catal5010018

来源: mdpi

【 摘 要 】

The continuous flow Suzuki-Miyaura reaction between various haloarenes and arylboronic acids was successfully achieved within only ca. 20 s during the single-pass through a cartridge filled with palladium on carbon (Pd/C). No palladium leaching was observed in the collected reaction solution by atomic absorption spectrometry (detection limit: 1 ppm).

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.