Increased Circulating Levels of Vitamin D Binding Protein in MS Patients

Toxins

Arturo Ottavio Rinaldi⁴  Isabella Sanseverino⁴  Cristina Purificato⁴  Antonio Cortese²  Rosella Mechelli³  Silvia Francisci¹  Marco Salvetti³  Enrico Millefiorini²  Sandra Gessani⁴  Maria Cristina Gauzzi⁴ 

[1] National Center for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità, Rome 00161, Italy; E-Mail:;Multiple Sclerosis Center, Sapienza University of Rome, Rome 00161, Italy; E-Mails:;Centre for Experimental Neurological Therapies (CENTERS) Department of Neurosciences, Mental Health and Sensory Organs Sapienza University, S. Andrea Hospital-site, Rome 00161, Italy; E-Mails:;Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome 00161, Italy; E-Mails:

关键词: vitamin D binding protein;    albumin;    relapsing/remitting multiple sclerosis;    beta-interferon;    immunology;    vitamin D;   

DOI  :  10.3390/toxins7010129

来源: mdpi

【 摘 要 】

Vitamin D (vitD) low status is currently considered a main environmental factor in multiple sclerosis (MS) etiology and pathogenesis. VitD and its metabolites are highly hydrophobic and circulate mostly bound to the vitamin D binding protein (DBP) and with lower affinity to albumin, while less than 1% are in a free form. The aim of this study was to investigate whether the circulating levels of either of the two vitD plasma carriers and/or their relationship are altered in MS. We measured DBP and albumin plasma levels in 28 MS patients and 24 healthy controls. MS patients were found to have higher DBP levels than healthy subjects. Concomitant interferon beta therapy did not influence DBP concentration, and the difference with the control group was significant in both females and males. No significant correlation between DBP and albumin levels was observed either in healthy controls or in patients. These observations suggest the involvement of DBP in the patho-physiology of MS.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.